Lung Compliance and its Mechanical Functions
طب بشري | Medicine
جامعة الخليج العربي
- 2024-11-24
Lung Compliance
Definition: Lung compliance is a measure of the lung's ability to stretch and expand. It is defined as the change in lung volume (ΔV) per unit change in transpulmonary pressure (ΔP).
High Compliance: Indicates that the lungs can expand easily. This can be seen in conditions like emphysema, where the lung tissue is damaged, losing its elasticity,
and making it easier to inflate but harder to deflate.
Low Compliance: Indicates that the lungs are stiff and hard to expand. This can occur in pulmonary fibrosis,
where scar tissue
forms in the lungs, making them less elastic and more difficult to inflate.
Mechanical Properties of Lungs
Elasticity: The lungs are elastic due to the presence of elastic fibers in the lung tissue.
This elasticity allows the lungs to recoil and return to their original shape after being stretched during inhalation.
Elastic recoil is important for passive exhalation.
Surface Tension: The alveoli are lined with a thin layer of fluid that creates surface tension.
This tension is reduced by a substance called surfactant, produced by type II alveolar cells.
Surfactant reduces surface tension, preventing alveolar collapse (atelectasis) and making it easier for the lungs to expand during inhalation.
Airway Resistance: Airway resistance is the resistance to airflow within the respiratory tract.
It is influenced by the diameter of the airways and the viscosity of the air.
Conditions like asthma or chronic obstructive pulmonary disease (COPD) can increase airway resistance, making it harder to breathe.
Viscoelastic Properties: Lung tissue exhibits both viscous and elastic properties. The elastic component allows the lungs to stretch and recoil,
while the viscous component allows the lungs to adapt to changes in volume and pressure over time, ensuring smooth and efficient breathing cycles.
Clinical Relevance
Emphysema: Characterized by high lung compliance due to the destruction of elastic fibers. Patients have difficulty exhaling air, leading to hyperinflation of the lungs.
Pulmonary Fibrosis: Characterized by low lung compliance due to the formation of scar tissue. Patients have difficulty inhaling air, resulting in reduced lung volumes.
Asthma: Increased airway resistance due to bronchoconstriction. Patients experience difficulty in both inhalation and exhalation, often requiring medication to dilate the airways.
Surfactant Deficiency: Conditions like neonatal respiratory distress syndrome occur
in premature infants who lack adequate surfactant. This results in high surface tension and alveolar collapse, making breathing difficult.
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