Cardiology - Pathophysiology and types of Arrhythmias

طب بشري | Medicine 


جامعة الكويت
  • 2025-04-09

1. Introduction to Cardiac Arrhythmias

Arrhythmias are disturbances in the heart’s normal electrical rhythm. In a healthy heart, 

the sinoatrial (SA) node initiates an electrical impulse that travels in an orderly fashion through the atria,

 the atrioventricular (AV) node, the bundle of His, and finally the Purkinje fibers to stimulate coordinated ventricular contraction.

 Any abnormality in the generation or propagation of these impulses can result in an arrhythmia. These disturbances are not necessarily caused by

 structural problems alone; they may also arise from altered cellular function or systemic perturbations such as electrolyte imbalances or hormonal disorders .

2. The Cardiac Conduction System & Electrophysiology

The cardiac conduction system is specialized tissue that ensures the heart contracts in a synchronized, efficient manner. Key components include:

Sinoatrial (SA) Node: Often referred to as the natural pacemaker, it initiates and sets the pace of the heartbeat.

Atrioventricular (AV) Node: This structure introduces a critical delay, letting the atria contract and fill the ventricles before the latter contract.

Bundle of His and Purkinje Fibers: These pathways rapidly conduct the impulse throughout the ventricles.

The integrity of this system is crucial for maintaining a regular heart rate. Alterations—whether from congenital defects,

 ischemic injury, or age‐related degeneration—can disrupt the orderly conduction, predisposing the heart to arrhythmias .

3. Pathophysiologic Mechanisms of Arrhythmogenesis

Understanding why arrhythmias develop involves exploring the underlying electrophysiological mechanisms. Three primary mechanisms have been identified:

Abnormal Automaticity: Under normal conditions, pacemaker cells in the SA node set a definitive rate; however,

 when cells from other parts of the heart begin spontaneously generating impulses, 

they can override the normal rhythm. This can occur if there are alterations in ion channel 

function or membrane potential, leading to decreased threshold potentials in non-pacemaking cells .

Reentry: Reentry is the most common mechanism and occurs when an electrical impulse fails to extinguish after a normal contraction and 

instead re-circulates within a region of the heart. Structural barriers (such as scar tissue following myocardial infarction)

 or areas of slowed conduction create a unidirectional block, allowing the impulse to loop back on itself.

 This circuit perpetuates rapid or chaotic rhythms and can be life-threatening in conditions like ventricular tachycardia .

Triggered Activity: This mechanism involves abnormal impulse generation that follows the completion of the action potential.

 It is characterized by early afterdepolarizations (EADs) or delayed afterdepolarizations (DADs),

 which occur due to disturbances in calcium handling or other ionic imbalances.

 They can provoke an extra beat or sustained arrhythmias, especially under the influence of certain drugs or electrolyte abnormalities 

Each of these mechanisms can be influenced by a variety of factors including ischemia, electrolyte disturbances

 (e.g., hypokalemia or hypomagnesemia), drugs, and genetic predisposition. The interplay of these elements determines whether the arrhythmia will be benign or of clinical concern .

4. Types of Arrhythmias

Arrhythmias are broadly classified based on the speed of the heart rate and the location of their origin:

A. Bradyarrhythmias

These arrhythmias are characterized by a slower than normal heart rate and can be due to:

Sinus Node Dysfunction: The SA node fails to generate impulses at a normal rate.

Atrioventricular (AV) Block: Impaired conduction through the AV node can lead to partial or complete disassociation between atrial and ventricular activity.

Bradyarrhythmias may result in inadequate cardiac output and syncope, among other symptoms.

B. Tachyarrhythmias

Tachyarrhythmias involve a faster than normal heart rate and can be further subdivided by the site of origin:

Supraventricular Tachycardias (SVT):

Atrial Fibrillation (AF): Characterized by disorganized atrial electrical activity resulting in an irregularly irregular rhythm.

Atrial Flutter: Often features a rapid but regular atrial rhythm due to a reentrant circuit in the atria.

Paroxysmal SVT: Sudden onset rapid heart rates that begin and terminate abruptly.

Ventricular Tachyarrhythmias:

Ventricular Tachycardia (VT): A fast, regular rhythm that originates from abnormal foci in the ventricles.

Ventricular Fibrillation (VF): Chaotic electrical activity in the ventricles causing disorganized contraction, 

which is immediately life-threatening if not promptly treated.

In addition to rate-based classification, some arrhythmias are associated with congenital abnormalities 

(such as accessory pathways seen in Wolff-Parkinson-White syndrome) or

 with ion channelopathies (such as long QT syndrome, Brugada syndrome) which predispose patients to dangerous arrhythmias .

5. Clinical Implications and Diagnostic Evaluation

Arrhythmias can be asymptomatic, or they may present with palpitations, dizziness, dyspnea, chest pain, or syncope. The diagnosis is made via:

Electrocardiography (ECG): The primary tool for detecting rhythm disturbances, assessing rate, rhythm regularity, and the morphology of electrical activity.

Holter Monitoring/Event Recorders: For intermittent arrhythmias that are not captured on a routine ECG.

Electrophysiological Studies: Invasive tests that pinpoint the origin and reentrant pathways of arrhythmias, 

especially when planning therapeutic interventions .

Management strategies will vary—from pharmacotherapy (using antiarrhythmic drugs)

 to invasive procedures like catheter ablation—depending on the underlying mechanism and severity of the arrhythmia

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Mohammed Adel

 

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